Label-free Biosensing Using Cascaded Silicon-on-insulator Micro-racetrack Resonators Integrated with Pdms Microfluidic Channels
نویسندگان
چکیده
This paper demonstrates a label-free biosensing platform using Silicon-On-Insulator (SOI) micro-racetrack resonators, cascaded such that multiple measurements can be made using a single input and output waveguide and therefore a single detector. The devices are integrated with poly(dimethylsiloxane) microfluidic channels in order to characterize the devices’ sensing properties. Both bulk refractive index sensing using glycerin/water solutions and clinically-relevant biosensing using Human Factor IX and its corresponding antibody are characterized. Bulk sensitivities of 40 nm/RIU are achieved, and the devices are able to sense both the protein attachment during functionalization and the protein-antibody binding reaction.
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